The concomitant administration with the protease inhibitor ritonavir substantially boosts serum concentrations of sildenafil (11-fold rise in AUC). If VIAGRA is prescribed to people getting ritonavir, warning ought to be applied. Details from topics exposed to substantial systemic amounts of sildena

This metabolite has a PDE selectivity profile just like sildenafil and an in vitro potency for PDE5 roughly 50% with the mother or father drug. Plasma concentrations of this metabolite are roughly 40% of All those witnessed for sildenafil, so which the metabolite accounts for around twenty% of silde

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